Piero Bosio Social Web Site Personale

OpenStreetMap contributors can have a car running gotosocial, as a treat

opera: Michela Castellana, acquerello ... https://cctm.website/michela-castellana-italia/#MichelaCastellana #art #cctmwebsite #anoipiaceleggere #leggere

scha·den·freu·de (@blisterpearl.bsky.social)https://bsky.app/profile/blisterpearl.bsky.social/post/3ma27hiveyc2s> Not sharing the Trump/Reiner post because it's rage-bait. I know this because it baited my rage. Here is a kitten:

Baring your soul. Repeatedly. | More comics: https://rooniecomics.com/comics/winter-trees

Need to see the calendar for this month? Simply type "cal". To see thewhole year, type "cal -y". -- Dru <genesis@istar.ca>

Pufferfish Venom Can Kill, Or It Can Relieve PainTetrodotoxin (TTX) is best known as the neurotoxin of the puffer fish, though it also appears in a range of other marine species. You might remember it from an episode of The Simpsons involving a poorly prepared dish at a sushi restaurant. Indeed, it’s a potent thing, as ingesting even tiny amounts can lead to death in short order.Given its fatal reputation, it might be the last thing you’d expect to be used in a therapeutic context. And yet, tetrodotoxin is proving potentially valuable as a treatment option for dealing with cancer-related pain. It’s a dangerous thing to play with, but it could yet hold promise where other pain relievers simply can’t deliver.Poison, or…?A license to prepare fugu (pufferfish) issued by Tokyo authorities. Credit: Nesnad, CC BY SA 3.0Humans have been aware of the toxicity of the puffer fish and its eggs for thousands of years. It was much later that tetrodotoxin itself was chemically isolated, thanks to the work of Dr. Yoshizumi Tahara in 1909.Its method of action was proven in 1964, with tetrodotoxin found to bind to and block voltage-gated sodium channels in nerve cell membranes, essentially stopping the nerves from conducting signals as normal. It thus has the effect of inducing paralysis, up to the point where an afflicted individual suffers respiratory failure, and subsequently, death.Tetrodotoxin is most closely associated with pufferfish, though it’s also present in other deadly species, like the blue-ringed octopus. Thankfully, nobody is crazy enough to try to eat those. Credit: NPS, public domainIt doesn’t take a large dose of tetrodotoxin to kill, either—the median lethal dose in mice is a mere 334 μg per kilogram when ingested. The lethality of tetrodotoxin was historically a prime driver behind Japanese efforts to specially license chefs who wished to prepare and serve pufferfish. Consuming pufferfish that has been inadequately prepared can lead to symptoms in 30 minutes or less, with death following in mere hours as the toxin makes it impossible for the sufferer to breathe. Notably, though, with the correct life support measures, particularly for the airway, or with a sub-fatal dose, it’s possible for a patient to make a full recovery in mere days, without any lingering effects.The effects that tetrodotoxin has on the nervous system are precisely what may lend it therapeutic benefit, however. By blocking sodium channels in sensory neurons that deal with pain signals, the toxin could act as a potent method of pain relief. Researchers have recently explored whether it could have particular application for dealing with neuropathic pain caused by cancer or chemotherapy treatments. This pain isn’t always easy to manage with traditional pain relief methods, and can even linger after cancer recovery and when chemotherapy has ceased.Tetrodotoxin is able to block voltage-gated sodium channels, which is the basis of both its pain-relieving abilities and its capacity to paralyze and kill. Credit: research paperThe challenge of using a toxin for pain relief is obvious—there’s always a risk that the negative effects of the toxin will outweigh the supposed therapeutic benefit. In the case of tetrodotoxin, it all comes down to dosage. The levels given to patients in research studies have been on the order of 30 micrograms, well under the multi-milligram dose that would typically cause severe symptoms or death in an adult human. The hope would be to find a level at which tetrodotoxin reduces pain with a minimum of adverse effects, particularly where symptoms like paralysis and respiratory failure are on the table.A review of various studies worldwide was published in 2023, and highlights that tetrodotoxin pain relief does come with some typical adverse effects, even at tiny clinical doses. The most typical reported symptoms involved nausea, oral numbness, dizziness, and tingling sensations. In many cases, these effects were mild and well-tolerated. A small number of patients in research trials exhibited more serious symptoms, however, such as loss of muscle control, pain, or hypertension. At the same time, the treatment did show positive results — with many patients reporting pain relief for days or even weeks after just a few days of tetrodotoxin injections.While tetrodotoxin has been studied as a pain reliever for several decades now, it has yet to become a mainstream treatment. There have been no large-scale studies that involved treating more than 200 patients, and no research group or pharmaceutical company has pushed hard to bring a tetrodotoxin-based product to market. Research continues, with a 2025 paper even exploring the use of ultra-low nanogram-scale doses in a topical setting. For now, though, commercial application remains a far-off fantasy. Today, the toxin remains the preserve of pufferfish and a range of other deadly species. Don’t expect to see it in a hospital ward any time soon, despite the promise it shows thus far.Featured image: “Puffer Fish DSC01257.JPG” by Brocken Inaglory. Actually, not one of the poisonous ones, but it looked cool.hackaday.com/2025/12/15/puffer…

@las_lallero @ciccio2000 @renatoram @ChieseBrutte @samatari2 @Uilebheist @panda4x4 @wilde_brut89 lenzuola annodate? 30 metri di corda elfica in borsetta quando si va al lavoro?

@elzazo Diciamo che inizio a prenderci la mano. :D

@vivasupeR Non vedono l'ora di farlo, guarda.

Hi all my name is Stuart, but you can all call me by Stu.I am a Engineer who builds custom conveyor guards out of stainless steel material with Solidworks and AutoCAD.I am big fan of all music and genres.I love open source and decentralized platforms.I love to play Golf when I have time and money.#introduction

The Tepid Emperor (@thetepidemperor.mastodon.social.ap.brid.gy)https://bsky.app/profile/thetepidemperor.mastodon.social.ap.brid.gy/post/3m7zogscirv72> Now wrapping presents to this… featuring @Skeewiff #ChristmasWrapping

But, as with any democracy, the way you fix this is by swapping out the bad leaders for good ones - not by abolishing democracy and replacing it with an atomized society in which it's every worker for themself, bargaining with a boss who will always win a one-on-one fight in the long run.I raise this because a general strike is back on the table, likely for May Day 2028 (5/1/28):https://labornotes.org/2025/12/maybe-general-strike-isnt-so-impossible-now10/

Vita di merda. Mi hanno messo sotto in bici ma dovevo scappare per cui ho dovuto dirgli: c'ho fretta ci vediamo domani per fare a botte? Così si perde tutta la poesia però.

Frequently /me [from DE] thinks about #Datensparsamkeit The officially best [en] explainer is https://martinfowler.com/bliki/Datensparsamkeit.html@mfowler I became a Carteret Islands person once.Looking at my shell neclace.My wish for christmas is that you read it and carefully think about all the things you publish in terms of accessibility but also formats and size.An example:For @clemensg I did the yearly #ActivityPub #Atlas - it comes with millions and millions of geohashed places for OSM, wikidata, official sources and, well openaddresses [.io] They publish primarily in texts with lines of geojson.The whole planet is about 46 GB … … …An exmple:DE in this "format" is about 3.2 GBDE in CSV would be maybe 1.5 GB If we normalize and publish it compressed, it is [incl geohashes] about 800MB. If we now compress the geohashes, expanding it clientside the 3.2 GB becomes 250 MB …Maybe we can't save tons of powerplants like banning bitcoin would.But together we can save lots of energy.#geojson 💣

Disertare la guerra – prendersi cura della terra. Per una gestione collettiva di territori e risorse@anarchia Nel fine settimana del 29 e 30 novembre 2025, come gruppo anarchico Mikhail Bakunin FAI di Roma&Lazio, abbiamo preso parte a due iniziative diverse per forma ma profondamente unite nel contenuto: il 29 novembre ’25 al corteo

RE: https://mastodon.online/@mwichary/115724724577548130Boosting for exposure. If you have any historical insights into early HTML syntax, please check this entire thread out.

@snow ho una cattiva (?) notizia per te: con xmpp lo spazio libero rimane libero, un server xmpp è davvero poco esoso di risorse :D

@GustavinoBevilacqua Se si chiama rischio di impresa, ci sarà il suo bel perché.

@rojun @adapalmer the whole plebeians thing in Rome was more a new money vs old money thing, nobody expected the actual workers to get access to the positions of power that got opened to plebeians

@fiee @MicroSFF they would be quite useful to catch a train you are just a bit too late for, especially when you can see the platform from the street, but have to walk all around the station to get to itI may have wished for teleportation in the visual range quite a number of times back when I commuted :D